Estriol 16α-(β-D-glucuronide)

Names

[ Name ]:
Estriol 16α-(β-D-glucuronide)

[Synonym ]:
estriol 16 glucuronide
Estriol O16-glucuronide

Biological Activity

[Description]:

Estriol 16α-(β-D-glucuronide) is an endogenous metabolite present in Urine that can be used for the research of Pregnancy[1][2].

[Related Catalog]:

Research Areas >> Others

[In Vitro]

Endogenous metabolites is defined as those that are annotated by Kyoto Encyclopedia of Genes and Genomes as substrates or products of the ~1900 metabolic enzymes encoded in our genome. It is clear in the body of literature that there are documented toxic properties for many of these metabolites[1].

[References]

[1]. Lee N, et al. Endogenous toxic metabolites and implications in cancer therapy. Oncogene. 2020 Aug;39(35):5709-5720.

[2]. Yang YJ, et al. Direct determination of estriol 3- and 16-glucuronides in pregnancy urine by column-switching liquid chromatography with electrospray tandem mass spectrometry. Biomed Chromatogr. 2003 Jun;17(4):219-25.

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
738.3ºC at 760mmHg

[ Molecular Formula ]:
C₂₄H₃₂O₉

[ Molecular Weight ]:
464.50500

[ Flash Point ]:
253.5ºC

[ Exact Mass ]:
464.20500

[ PSA ]:
156.91000

[ LogP ]:
0.49650

[ Vapour Pressure ]:
6.95E-23mmHg at 25°C

[ Index of Refraction ]:
1.667

[ Storage condition ]:
-20°C

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H351

[ Precautionary Statements ]:
P281

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
40

[ Safety Phrases ]:
36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Articles

Radioimmunoassay of 2-hydroxyestrone.

Steroids 31(2) , 249-58, (1978)

Under the protection of ascorbic acid a 2-hydroxyestrone bovine serum albumin conjugate was prepared containing intact 2-hydroxyestrone as determined by gas chromatographymass spectometry. Using this ...

The dynamic changes of several reproductive hormones during termination of early pregnancy by RU486 in combination with PG-05 in Chinese women.

Adv. Contracept. 4(4) , 319-26, (1988)

8 pregnant women (below 49 days of amenorrhea) were administered 600 mg RU486 orally in a single dosage, and 1 mg PG-05 as a vaginal suppository 48 h afterwards. The plasma beta-hCG, progesterone, 17 ...

Associations between urinary phthalate monoesters and thyroid hormones in pregnant women.

Hum. Reprod. 22(10) , 2715-22, (2007)

Maternal hypothyroidism during pregnancy can cause adverse effects in the fetus. Scientific evidence has shown that probable thyroid-like function of some phthalates in vitro and in vivo, and phthalat...

Related Compounds

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