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VU 0650786

Names

[ CAS No. ]:
1809085-30-0

[ Name ]:
VU 0650786

Biological Activity

[Description]:

VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> mGluR
Research Areas >> Neurological Disease

[Target]

mGluR3:392 nM (IC50)


[References]

[1]. Engers JL, et al. Discovery of a Selective and CNS Penetrant Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 3 with Antidepressant and Anxiolytic Activity in Rodents. J Med Chem. 2015 Sep 24;58(18):7485-500.

Chemical & Physical Properties

[ Molecular Formula ]:
C18H15ClFN5O2

[ Molecular Weight ]:
387.80

[ Storage condition ]:
2-8℃

Related Compounds