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Fmoc-PEG1-NHS ester

Names

[ CAS No. ]:
1807521-05-6

[ Name ]:
Fmoc-PEG1-NHS ester

Biological Activity

[Description]:

Fmoc-PEG1-CH2CH2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

Alkyl/ether


[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Molecular Formula ]:
C24H24N2O7

[ Molecular Weight ]:
452.46

Related Compounds