Peiminine

Names

[ Name ]:
Peiminine

[Synonym ]:
MFCD00210542
(3β)-3,20-Dihydroxycevan-6-one
Osnovanine
Raddeamine
(3β,5α)-3,20-Dihydroxycevan-6-one
Cevan-6-one, 3,20-dihydroxy-, (3β,5α)-
Sipeimine
3beta,20-Dihydroxy-5alpha-cevan-6-one
3β,20-Dihydroxy-5α-cevan-6-one
(3b)-3,20-Dihydroxycevan-6-one
RADDEANINE
Cevan-6-one, 3,20-dihydroxy-, (3β)-
cevan-6-one, 3,20-dihydroxy-, (3b)-
PEINININE
Fritillarine
Verticinone

Biological Activity

[Description]:

Peiminine(Verticinone; Raddeanine) is a natural compound with anti-inflammatory activity.IC50 value:Target:Peiminine and DXS significantly reduced alveolar inflammation and pulmonary interstitial inflammation in rats with bleomycin-induced lung injury. peiminine inhibits lung inflammation and pulmonary fibrosis in a rat model of bleomycin-induced lung injury, by reducing circulating IFN-γ levels and inhibiting signal transduction pathways involving TGF-β, CTGF, ERK1/2, NF-κB and FasL.

[Related Catalog]:

Signaling Pathways >> Autophagy >> Autophagy

Natural Products >> Alkaloid

Research Areas >> Inflammation/Immunology

[References]

[1]. Guo H, et al. Peiminine ameliorates bleomycin-induced acute lung injury in rats. Mol Med Rep. 2013 Apr;7(4):1103-10.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
567.1±50.0 °C at 760 mmHg

[ Melting Point ]:
212-213ºC

[ Molecular Formula ]:
C₂₇H₄₃NO₃

[ Molecular Weight ]:
429.635

[ Flash Point ]:
296.8±30.1 °C

[ Exact Mass ]:
429.324280

[ PSA ]:
60.77000

[ LogP ]:
3.90

[ Vapour Pressure ]:
0.0±3.5 mmHg at 25°C

[ Index of Refraction ]:
1.585

Safety Information

[ Hazard Codes ]:
Xi

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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