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CT7001 hydrochloride

Names

[ CAS No. ]:
1805789-54-1

[ Name ]:
CT7001 hydrochloride

[Synonym ]:
PPDA-001 HCL SALT
CT7001 hydrochloride

Biological Activity

[Description]:

CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.

[Related Catalog]:

Research Areas >> Cancer

[Target]

CDK7/CycH/MAT1:41 nM (IC50)

CDK2/cycE1:578 nM (IC50)


[In Vitro]

CT7001 (ICEC0942) is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively[1].

[Kinase Assay]

The purified recombinant CDK2/cycE1 and CDK7/CycH/MAT1 are used in the assay. Kinase assays are performed. Briefly, Rb-CTF and RNA Polymerase II peptide is used for CDK2 and CDK7 kinase assays, respectively. A luciferase assay is used to determine ATP remaining at the end of the kinase reaction, which provides a measure of kinase activity. GraphPad Prism Software is used to generate the IC50 values for each CDK[1].

[References]

[1]. Hazel P, et al. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem. 2017 Mar 7;12(5):372-380.


[Related Small Molecules]

Abemaciclib(LY2835219) | Ribociclib (LEE011) | Dinaciclib (SCH727965) | THZ1 2HCl | Roscovitine (CYC202) | THZ531 | RO-3306 | Flavopiridol | NVP 2 | BAY-1143572 Racemate | CYC-065 | AZD5438 | BIO | Kenpaullone | SNS-032 (BMS-387032)

Chemical & Physical Properties

[ Molecular Formula ]:
C22H31ClN6O

[ Molecular Weight ]:
430.97

[ Storage condition ]:
2-8℃

Related Compounds