1805789-54-1

1805789-54-1 structure

Name: CT7001 hydrochloride
Chemical Name: 3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
CAS Number: 1805789-54-1
Molecular Formula: C₂₂H₃₁ClN₆O
Molecular Weight: 430.97
Catalog: Research Areas Cancer
Create Date: 2018-06-25 08:27:09
Modify Date: 2024-02-10 23:57:20
CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.

Name	3-Piperidinol, 4-[[[3-(1-methylethyl)-7-[(phenylmethyl)amino]pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]-, hydrochloride (1:1), (3R,4R)-
Synonyms	PPDA-001 HCL SALT CT7001 hydrochloride

Description	CT7001 hydrochloride is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively.
Related Catalog	Research Areas >> Cancer
Target	CDK7/CycH/MAT1:41 nM (IC50) CDK2/cycE1:578 nM (IC50)
In Vitro	CT7001 (ICEC0942) is a selective CDK7 inhibitor, with IC50s of 41 nM and 578 nM for CDK7/CycH/MAT1 and CDK2/cycE1, respectively[1].
Kinase Assay	The purified recombinant CDK2/cycE1 and CDK7/CycH/MAT1 are used in the assay. Kinase assays are performed. Briefly, Rb-CTF and RNA Polymerase II peptide is used for CDK2 and CDK7 kinase assays, respectively. A luciferase assay is used to determine ATP remaining at the end of the kinase reaction, which provides a measure of kinase activity. GraphPad Prism Software is used to generate the IC50 values for each CDK[1].
References	[1]. Hazel P, et al. Inhibitor Selectivity for Cyclin-Dependent Kinase 7: A Structural, Thermodynamic, and Modelling Study. ChemMedChem. 2017 Mar 7;12(5):372-380.