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SNC 162

Names

[ CAS No. ]:
178803-51-5

[ Name ]:
SNC 162

[Synonym ]:
snc 162

Biological Activity

[Description]:

SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

IC50: 0.94 nM (delta-opioid receptor)[1]


[References]

[1]. Jutkiewicz EM, et al. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81.

[2]. Banks ML, et al. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacol Biochem Behav. 2010 Dec;97(2):205-12.

Chemical & Physical Properties

[ Density]:
1.027g/cm3

[ Boiling Point ]:
536.4ºC at 760mmHg

[ Molecular Formula ]:
C27H37N3O

[ Molecular Weight ]:
419.60

[ Flash Point ]:
202.4ºC

[ Exact Mass ]:
419.29400

[ PSA ]:
26.79000

[ LogP ]:
4.71440

[ Vapour Pressure ]:
1.4E-11mmHg at 25°C

[ Index of Refraction ]:
1.549

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds