178803-51-5

178803-51-5 structure

Name: SNC 162
Chemical Name: 4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
CAS Number: 178803-51-5
Molecular Formula: C₂₇H₃₇N₃O
Molecular Weight: 419.60
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-12-21 23:09:59
Modify Date: 2024-01-28 19:05:34
SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys[1][2].

Name	4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
Synonyms	snc 162

Description	SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	IC50: 0.94 nM (delta-opioid receptor)[1]
References	[1]. Jutkiewicz EM, et al. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81. [2]. Banks ML, et al. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacol Biochem Behav. 2010 Dec;97(2):205-12.

611-95-0

178803-51-5

67055-76-9

178803-51-5

186094-07-5

178803-51-5

2815-34-1

178803-51-5

Precursor 3
611-95-0 67055-76-9 2815-34-1
DownStream 0