A2AAR antagonist 1

Names

[ CAS No. ]:
1784491-64-0

[ Name ]:
A2AAR antagonist 1

Biological Activity

[Description]:

A2AAR antagonist 1 (compound 21a) is an A2AAR (adenosine A2A receptor) antagonist with a Ki value of 20 nM. A2AAR antagonist 1 shows high ligand efficiency, and it can be used for the research of neurodegenerative diseases[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Neurological Disease

[In Vitro]

A2AAR antagonist 1 (0-10 μM; 1 h) shows a high affinity towards A2AAR with a Ki value of 20 nM[1].

[References]

[1]. Bolteau R, et al. High ligand efficiency quinazoline compounds as novel A2A adenosine receptor antagonists. Eur J Med Chem. 2022 Nov 5;241:114620.

Chemical & Physical Properties

[ Molecular Formula ]:
C12H8BrN3O

[ Molecular Weight ]:
290.12

Related Compounds