NPS ALX Compound 4a dihydrochloride

Names

[ CAS No. ]:
1781934-44-8

[ Name ]:
NPS ALX Compound 4a dihydrochloride

Biological Activity

[Description]:

NPS ALX Compound 4a dihydrochloride is a potent and selective 5-hydroxytryptamine6 (5-HT6) receptor antagonist with an IC50 of 7.2 nM and a Ki of 0.2 nM[1].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT6 Receptor:7.2 nM (IC50)

5-HT6 Receptor:0.2 nM (Ki)

[References]

[1]. Isaac M, et al. 6-Bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindolesderivatives as novel, potent, and selective 5-HT6 receptor antagonists. Bioorg Med Chem Lett. 2000 Aug 7;10(15):1719-21.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₅H₂₇Cl₂N₃O₂S

[ Molecular Weight ]:
504.47

Related Compounds

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