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Nociceptin (1-13) amide trifluoroacetate salt

Names

[ CAS No. ]:
178064-02-3

[ Name ]:
Nociceptin (1-13) amide trifluoroacetate salt

[Synonym ]:
phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-nh2
h-phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-nh2
phe-gly-gly-phe-thr-gly-ala-arg-lys-nh2

Biological Activity

[Description]:

Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Opioid Receptor
Signaling Pathways >> Neuronal Signaling >> Opioid Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 0.75 nM (binding to rat forebrain membranes)[1] pEC50: 7.9 (in mouse vas deferens)[2]


[References]

[1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90.

[2]. Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.

Chemical & Physical Properties

[ Molecular Formula ]:
C61H100N22O15

[ Molecular Weight ]:
1381.59

[ Exact Mass ]:
1380.77000

[ PSA ]:
634.61000

[ LogP ]:
1.06750

Related Compounds