178064-02-3

178064-02-3 structure

Name: Nociceptin (1-13) amide trifluoroacetate salt
Chemical Name: Nociceptin (1-13)NH2
CAS Number: 178064-02-3
Molecular Formula: C₆₁H₁₀₀N₂₂O₁₅
Molecular Weight: 1381.59
Catalog: Signaling Pathways GPCR/G Protein Opioid Receptor
Create Date: 2018-12-18 17:18:40
Modify Date: 2024-01-02 19:04:04
Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].

Name	Nociceptin (1-13)NH2
Synonyms	phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-nh2 h-phe-gly-gly-phe-thr-gly-ala-arg-lys-ser-ala-arg-lys-nh2 phe-gly-gly-phe-thr-gly-ala-arg-lys-nh2

Description	Nociceptin (1-13), amide is a potent ORL1 (OP4) receptor agonist with a pEC50 of 7.9 for mouse vas deferens and a Ki of 0.75 nM for binding to rat forebrain membranes[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	Ki: 0.75 nM (binding to rat forebrain membranes)[1] pEC50: 7.9 (in mouse vas deferens)[2]
References	[1]. Varani K, et al. Nociceptin receptor binding in mouse forebrain membranes: thermodynamic characteristics and structure activity relationships. Br J Pharmacol. 1998 Dec;125(7):1485-90. [2]. Calo' G, et al. Pharmacology of nociceptin and its receptor: a novel therapeutic target. Br J Pharmacol. 2000 Apr;129(7):1261-83.