hBChE-IN-1

Names

[ CAS No. ]:
1776948-12-9

[ Name ]:
hBChE-IN-1

Biological Activity

[Description]:

hBChE-IN-1 (compound 4), a quinolizidinyl derivative, is a potent hBChE inhibitor (IC50=7 nM) and highly selective over hAChE. hBChE-IN-1 shows inhibitory activity against tau and Aβ40 protein aggregation, with IC50 values of 20 and 4.3 μM, respectively. hBChE-IN-1 can be used for Alzheimer's disease research[1].

[Related Catalog]:

Research Areas >> Neurological Disease
Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

hBCHE:0.0070 ± 0 μM (IC50)

equine serum BChE:0.088 μM (IC50)

EeAChE:0.18 μM (IC50)

hAChE:7.84 ± 0.8 μM (IC50)


[References]

[1]. Tonelli M, et al. Thioxanthenone-based derivatives as multitarget therapeutic leads for Alzheimer's disease. Eur J Med Chem. 2023 Mar 15;250:115169.  

Chemical & Physical Properties

[ Molecular Formula ]:
C27H34N2OS2

[ Molecular Weight ]:
466.70

Related Compounds

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