Fucosterol

Names

[ Name ]:
Fucosterol

[Synonym ]:
trans-24-Ethylidenecholesterol
D5-avenasterol
MFCD00037543
FUCOSTEROL
Fucosterin
trans-Stigmasta-5,24(28)-dien-3b-ol
24-ETHYLIDENCHOLEST-5-ENE-3B-OL

Biological Activity

[Description]:

Fucosterol is isolated from E. stolonifera with anti-adipogenic, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via modulation of PPARαand C/EBPαexpression.

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Epigenetics >> PARP

Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

PPARα; C/EBPα[1]

[In Vitro]

Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1].Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3]. Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 µg/ml, respectively[4]. Cell Viability Assay[1] Cell Line: 3T3-L1 adipocytes Concentration: 0 μM; 25 μM; 50 μM Incubation Time: 7 days Result: Inhibited PPARα and C/EBPα expression.

[In Vivo]

Fucosterol (orally adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses[2].

[References]

[1]. Jung HA, et al. Anti-adipogenic activity of the edible brown alga Ecklonia stolonifera and its constituent fucosterol in 3T3-L1 adipocytes. Arch Pharm Res. 2014 Jun;37(6):713-20.

[2]. Lee YS, et al. Anti-diabetic activities of fucosterol from Pelvetia siliquosa. Arch Pharm Res. 2004 Nov;27(11):1120-2.

[3]. Khanavi M, et al. Cytotoxicity of fucosterol containing fraction of marine algae against breast and colon carcinoma cell line. Pharmacogn Mag. 2012 Jan;8(29):60-4.

[4]. Caamal-Fuentes E, et al. Cytotoxic and antiproliferative constituents from Dictyota ciliolata, Padina sanctae-crucis and Turbinaria tricostata. Pharm Biol. 2014 Oct;52(10):1244-8.

Chemical & Physical Properties

[ Density]:
0.98 g/cm3

[ Boiling Point ]:
504.2ºC at 760 mmHg

[ Melting Point ]:
118-120ºC

[ Molecular Formula ]:
C₂₉H₄₈O

[ Molecular Weight ]:
412.69100

[ Flash Point ]:
220.3ºC

[ Exact Mass ]:
412.37100

[ PSA ]:
20.23000

[ LogP ]:
7.94490

[ Vapour Pressure ]:
2.8E-12mmHg at 25°C

[ Index of Refraction ]:
1.53

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Articles

Kinetics and molecular docking studies of an anti-diabetic complication inhibitor fucosterol from edible brown algae Eisenia bicyclis and Ecklonia stolonifera.

Chem. Biol. Interact. 206(1) , 55-62, (2013)

In the present study, we investigated the anti-diabetic potential of fucosterol by evaluating the ability of this compound to inhibit rat lens aldose reductase (RLAR), human recombinant aldose reducta...

The effect of traditional stir-frying process on hydrophilic and lipophilic antioxidant capacities of pine nut kernels.

Int. J. Food Sci. Nutr. 66 , 873-80, (2015)

The effect of traditional stir-frying process at different heating temperatures (50-150 °C) and time periods (5-20 min) on hydrophilic part (total and individual phenolics), lipophilic part (tocophero...

Inhibition of Mycobacterium tuberculosis growth by saringosterol from Lessonia nigrescens.

J. Nat. Prod. 64(11) , 1463-4, (2001)

Assay-guided fractionation of an antitubercular extract obtained from Lessonia nigrescens yielded the phytosterol saringosterol as its active component. No appreciable toxicity against Vero cells was ...