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CMI977

Names

[ CAS No. ]:
175212-04-1

[ Name ]:
CMI977

[Synonym ]:
Urea, N-hydroxy-N-propyl-
Q5WMS52P89
VNR0T3Q498
1-Hydroxy-1-propylurea

Biological Activity

[Description]:

CMI977 is a potent 5-Lipoxygenase (5-LO) inhibitor.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Research Areas >> Inflammation/Immunology

[In Vitro]

CMI977 is a potent 5-lipoxygenase (5-LO) inhibitor that intervenes in the production of leukotrienes and is presently being developed for the treatment of chronic asthma. It is a single enantiomer with an all-trans (2S,5S) configuration. Of the four isomers of CMI977, the S,S isomer is found to have the best biological activity and is selected for further development.

[References]

[1]. Xiong Cai, et al. Synthesis of CMI-977, a Potent 5-Lipoxygenase Inhibitor. Org. Proc. Res. Dev., 1999, 3 (1), pp 73-76.


[Related Small Molecules]

U73122 | Zileuton | ML355 | Nordihydroguaiaretic acid | Indirubin-3'-monoxime | Caffeic acid | marmesin | Malotilate | 4',5-Dihydroxyflavone | Enazadrem | LY 178002 | RWJ 63556 | S-2474 | 5-Lipoxygenase-In-1 | A-69412

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
233.6±23.0 °C at 760 mmHg

[ Molecular Formula ]:
C16H19FN2O4

[ Molecular Weight ]:
322.33

[ Flash Point ]:
95.0±22.6 °C

[ LogP ]:
0.52

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Storage condition ]:
2-8℃

Related Compounds