LY 178002

Names

[ CAS No. ]:
107889-32-7

[ Name ]:
LY 178002

[Synonym ]:
LY 178002

Biological Activity

[Description]:

LY 178002 is a potent inhibitor of 5-lipoxygenase, phospholipase A2, with IC50 of 0.6 μM for 5-1ipoxygenase, inhibits cellular production of LTB4 by human polymorphonuclear leukocytes, and shows relatively weak inhibition on cyclooxygenase.

[Related Catalog]:

Signaling Pathways >> Metabolic Enzyme/Protease >> 5-Lipoxygenase
Signaling Pathways >> Metabolic Enzyme/Protease >> Phospholipase
Research Areas >> Inflammation/Immunology

[Target]

5-Lipoxygenase (5-LPO):0.6 μM (IC50)

PLA2:6.3 μM (IC50)

FCO:4.2 μM (IC50)

Cyclooxygenase


[In Vitro]

LY178002 inhibits the generation of LTB4, PLA2 and FCO with IC50s of 0.1, 6.3 and 4.2 μM [1].

[In Vivo]

LY 178002 (50 mg/kg) inhibits soft tissue swelling in the uninjected paw by 81%, and inhibits bone damage in rats. The minimum effective dose for LY178002 is 10 mg/kg p.o. In the established FCA model LY178002 at 50 mg/kg p.o. inhibits the uninjected paw swelling by 75%[1].

[References]

[1]. Panetta JA, et al. The anti-inflammatory effects of LY178002 and LY256548. Agents Actions. 1989 Jun;27(3-4):300-2.


[Related Small Molecules]

U73122 | 4-Acetamidophenol | Aspirin | Zileuton | D609 | Paradol | Ginsenoside Rg3 | Ginsenoside Compound K | Xanthohumol | Ibuprofen | Darapladib | Diclofenac | ML355 | NS-398 | Meloxicam

Chemical & Physical Properties

[ Density]:
1.139g/cm3

[ Boiling Point ]:
489.9ºC at 760 mmHg

[ Molecular Formula ]:
C18H25NO2S

[ Molecular Weight ]:
319.46200

[ Flash Point ]:
250.1ºC

[ Exact Mass ]:
319.16100

[ PSA ]:
78.12000

[ LogP ]:
4.42450

[ Vapour Pressure ]:
3.2E-10mmHg at 25°C

[ Index of Refraction ]:
1.591

[ Storage condition ]:
2-8℃

Related Compounds