ly 272015 hydrochloride

Names

[ Name ]:
ly 272015 hydrochloride

[Synonym ]:
ly-272,015

Biological Activity

[Description]:

LY-272015 hydrochloride is an orally active, specific 5-HT2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats[1][2].

[Related Catalog]:

Research Areas >> Cardiovascular Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT2B Receptor

[References]

[1]. S W Watts, et al. 5-HT2B-receptor antagonist LY-272015 is antihypertensive in DOCA-salt-hypertensive rats. Am J Physiol. 1999 Mar;276(3):H944-52.

[2]. Kota Naito, et al. Signal Transduction Mechanism for Serotonin 5-HT2B Receptor-Mediated DNA Synthesis and Proliferation in Primary Cultures of Adult Rat Hepatocytes. Biol Pharm Bull. 2016;39(1):121-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₅ClN₂O₂

[ Molecular Weight ]:
372.88800

[ Exact Mass ]:
372.16000

[ PSA ]:
46.28000

[ LogP ]:
5.05380

[ Storage condition ]:
Store at +4°C

Related Compounds

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