Dyrk1A-IN-5

Names

[ Name ]:
Dyrk1A-IN-5

Biological Activity

[Description]:

Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research[1].

[Related Catalog]:

Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK

Research Areas >> Neurological Disease

[Target]

DYRK1A:6 nM (IC50)

DYRK1B:600 nM (IC50)

DYRK2:>10000 nM (IC50)

[References]

[1]. Falke H, et al. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem. 2015 Apr 9;58(7):3131-43.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₆H₉IN₂O₂

[ Molecular Weight ]:
388.16

Related Compounds

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