1685235-41-9

1685235-41-9 structure

Name: Dyrk1A-IN-5
Chemical Name: Dyrk1A-IN-5
CAS Number: 1685235-41-9
Molecular Formula: C₁₆H₉IN₂O₂
Molecular Weight: 388.16
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK DYRK
Create Date: 2022-08-04 17:26:38
Modify Date: 2024-01-10 07:04:25
Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research[1].

Name	Dyrk1A-IN-5

Description	Dyrk1A-IN-5 (compound 5j) is a potent and selective DYRK1A inhibitor, with an IC50 of 6 nM. Dyrk1A-IN-5 dose-dependently reduces the phosphorylation of Thr434 in SF3B1, with an IC50 of 0.5 μM. Dyrk1A-IN-5 inhibits phosphorylation of tau at Thr212, with an IC50 of 2.1 μM. Dyrk1A-IN-5 can be used for Down syndrome research[1].
Related Catalog	Signaling Pathways >> Protein Tyrosine Kinase/RTK >> DYRK Research Areas >> Neurological Disease
Target	DYRK1A:6 nM (IC50) DYRK1B:600 nM (IC50) DYRK2:>10000 nM (IC50)
References	[1]. Falke H, et al. 10-iodo-11H-indolo[3,2-c]quinoline-6-carboxylic acids are selective inhibitors of DYRK1A. J Med Chem. 2015 Apr 9;58(7):3131-43.

Molecular Formula	C₁₆H₉IN₂O₂
Molecular Weight	388.16