Hydroxy-PEG3-acrylate

Names

[ Name ]:
Hydroxy-PEG3-acrylate

[Synonym ]:
ethylenediglycol acrylate
EINECS 240-741-9
2-(2-(2-Hydroxyethoxy)ethoxy)ethyl acrylate
triethylene glycol monoacrylate

Biological Activity

[Description]:

Hydroxy-PEG3-acrylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> PROTAC >> PROTAC Linker

[Target]

PEGs

[In Vitro]

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[References]

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Chemical & Physical Properties

[ Density]:
1.098g/cm3

[ Boiling Point ]:
302.4ºC at 760mmHg

[ Molecular Formula ]:
C₉H₁₆O₅

[ Molecular Weight ]:
204.22000

[ Flash Point ]:
113ºC

[ Exact Mass ]:
204.10000

[ PSA ]:
64.99000

[ Vapour Pressure ]:
9.63E-05mmHg at 25°C

[ Index of Refraction ]:
1.453

Safety Information

[ HS Code ]:
2916129000

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2916129000

[ Summary ]:
2916129000 other esters of acrylic acid VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%