7-Desmethyl-3-hydroxyagomelatine

Names

[ Name ]:
7-Desmethyl-3-hydroxyagomelatine

Biological Activity

[Description]:

7-Desmethyl-3-hydroxyagomelatine (3-Hydroxy-7-desmethyl agomelatine), a metabolite of Agomelatine, has less activity than Agomelatine[1]. Agomelatine is a melatonergic (MT1 and MT2) agonist and serotonergic (5HT2C) antagonist[1][2].

[Related Catalog]:

Signaling Pathways >> Neuronal Signaling >> Melatonin Receptor

Signaling Pathways >> GPCR/G Protein >> Melatonin Receptor

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

MT1

MT2

5-HT2C Receptor

[References]

[1]. Li M, et al. Development and validation a LC-MS/MS method for the simultaneous determination of agomelatine and its metabolites, 7-desmethyl-agomelatine and 3-hydroxy-agomelatine in human plasma: Application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 15;1003:60-6.

[2]. Kennedy SH, et al. Agomelatine and its therapeutic potential in the depressed patient. Neuropsychiatr Dis Treat. 2007 Aug;3(4):423-8.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₄H₁₅NO₃

[ Molecular Weight ]:
245.2738

Related Compounds

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