Dinotefuran

Names

[ Name ]:
Dinotefuran

[Synonym ]:
Dinotefuran
UNII:1W509710WF
N-methyl-N’-nitro-N″-[(tetrahydro-3-furanyl)methyl]guanidine
2-methyl-1-nitro-3-(oxolan-3-ylmethyl)guanidine
1-Methyl-2-nitro-3-((tetrahydrofuran-3-yl)methyl)guanidine
Guanidine, N-methyl-N''-nitro-N'-[(tetrahydro-3-furanyl)methyl]-
1-Methyl-2-nitro-3-(tetrahydrofuran-3-ylmethyl)guanidin
(EZ)-(RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine
1-Methyl-2-nitro-3-(tetrahydro-3-furanylmethyl)guanidine
rac-(Ξ)-N-methyl-N″-nitro-N’-[(3R)-oxolan-3-ylmethyl]guanidine
(RS)-N-Methyl-N'-nitro-N''-[(tetrahydro-3-furanyl)methyl]guanidine
1-Methyl-2-nitro-3-(tetrahydrofuran-3-ylmethyl)guanidine

Biological Activity

[Description]:

Dinotefuran is an insecticide of the neonicotinoid class, its mechanism of action involves disruption of the insect's nervous system by inhibiting nicotinic acetylcholine receptors.Target: nAChR, Antiparasitic

[Related Catalog]:

Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR

Signaling Pathways >> Neuronal Signaling >> nAChR

Signaling Pathways >> Anti-infection >> Parasite

Research Areas >> Infection

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
334.5±34.0 °C at 760 mmHg

[ Melting Point ]:
107.5ºC

[ Molecular Formula ]:
C₇H₁₄N₄O₃

[ Molecular Weight ]:
202.211

[ Flash Point ]:
156.1±25.7 °C

[ Exact Mass ]:
202.106583

[ PSA ]:
91.47000

[ LogP ]:
-0.70

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.596

[ Storage condition ]:
0-6°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
Xn,N

[ Risk Phrases ]:
22-53-56-57

[ Safety Phrases ]:
61

[ RIDADR ]:
Controls insect pests such as aphids, whiteflies,thrips, leafhopper, leafminer, sawfly, mole cricket, whitegrubs, lacebugs, billbugs, beetles, mealybugs, sawfly lar-vae, and cockroaches in leafy vegetables, in residentialand commercial buildings, outd

[ HS Code ]:
2934100016

Synthetic Route

Click to get detail synthetic route

Customs

[ HS Code ]: 2932190090

[ Summary ]:
2932190090 other compounds containing an unfused furan ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Simultaneous determination of neonicotinoid insecticides in human serum and urine using diatomaceous earth-assisted extraction and liquid chromatography-tandem mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 969 , 85-94, (2014)

A rapid and sensitive analytical method was developed for simultaneous determination of eight neonicotinoid insecticides (acetamiprid, clothianidin, dinotefuran, flonicamid, imidacloprid, nitenpyram, ...

Simultaneous determination of neonicotinoid insecticides in sunflower-treated seeds (hull and kernel) by LC-MS/MS.

Food Addit. Contam. Part A. Chem. Anal. Control. Expo. Risk Assess. 33 , 442-51, (2016)

A validated analytical method to determine seven neonicotinoids (dinotefuran, nitenpyram, thiamethoxam, clothianidin, imidacloprid, acetamiprid and thiacloprid) in sunflower seeds (hull and kernel) us...

Biological Monitoring of Human Exposure to Neonicotinoids Using Urine Samples, and Neonicotinoid Excretion Kinetics.

PLoS ONE 11 , e0146335, (2016)

Neonicotinoids, which are novel pesticides, have entered into usage around the world because they are selectively toxic to arthropods and relatively non-toxic to vertebrates. It has been suggested tha...

Related Compounds

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