VU 0422288

Names

[ Name ]:
VU 0422288

[Synonym ]:
ML396
N-(3-Chloro-4-((5-chloropyridin-2-yl)oxy)phenyl)picolinamide
2-Pyridinecarboxamide, N-[3-chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl]-
N-{3-Chloro-4-[(5-chloro-2-pyridinyl)oxy]phenyl}-2-pyridinecarboxamide
MFCD28411626
VU0422288

Biological Activity

[Description]:

VU0422288 is a potent, selective, CNS-penetrant pan-Group III mGlu positive allosteric modulator with IC50 of 110/146/130 nM for mGlu8/7/4, respectively, displays >30-fold selectivity over groups I and II mGlus (mGlu1/2/3/5/6).

[References]

References 1. Jalan-Sakrikar N, et al. ACS Chem Neurosci. 2014 Dec 17;5(12):1221-37. View Related Products by Target mGluR

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
422.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₁Cl₂N₃O₂

[ Molecular Weight ]:
360.194

[ Flash Point ]:
209.4±28.7 °C

[ Exact Mass ]:
359.022827

[ LogP ]:
3.51

[ Vapour Pressure ]:
0.0±1.0 mmHg at 25°C

[ Index of Refraction ]:
1.671

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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