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K-Ras G12C-IN-2

Names

[ CAS No. ]:
1629267-75-9

[ Name ]:
K-Ras G12C-IN-2

[Synonym ]:
1-[3-(4-{[(4-Chloro-5-cyclopropyl-2-hydroxyphenyl)amino]acetyl}-1-piperazinyl)-1-azetidinyl]-2-propen-1-one
MFCD28359116
2-Propen-1-one, 1-[3-[4-[2-[(4-chloro-5-cyclopropyl-2-hydroxyphenyl)amino]acetyl]-1-piperazinyl]-1-azetidinyl]-

Biological Activity

[Description]:

K-Ras G12C-IN-2 is a novel and irreversible inhibitor of G12C mutant K-Ras protein.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras
Research Areas >> Cancer

[Target]

K-Ras G12C[1]


[In Vitro]

K-Ras G12C-IN-2 is a covalent kras g12c inhibitor extracted from patent WO2014152588A1, compound V-35[1].

[References]

[1]. Pingda Ren, et al. Covalent inhibitors of kras g12c. WO2014152588A1


[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | CASIN | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | K-Ras(G12C) inhibitor 12 | ZCL 278 | Y16

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
675.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C21H27ClN4O3

[ Molecular Weight ]:
418.917

[ Flash Point ]:
362.4±31.5 °C

[ Exact Mass ]:
418.177155

[ LogP ]:
1.59

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.666

[ Storage condition ]:
2-8℃

Related Compounds