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K-Ras G12C-IN-1

Names

[ CAS No. ]:
1629265-17-3

[ Name ]:
K-Ras G12C-IN-1

[Synonym ]:
1-(4-{[(2',6-Dichloro-4-methoxy-3-biphenylyl)amino]acetyl}-1-piperazinyl)-2-propen-1-one
2-Propen-1-one, 1-[4-[2-[(2',6-dichloro-4-methoxy[1,1'-biphenyl]-3-yl)amino]acetyl]-1-piperazinyl]-

Biological Activity

[Description]:

K-Ras G12C-IN-1 is a novel and irreversible inhibitor of mutant K-ras G12C extracted from patent WO 2014152588 A1.IC50 value:Target: K-ras G12C inhibitor

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Ras
Research Areas >> Cancer

[Related Small Molecules]

ARS-853 | ARS-1620 | NSC 23766 | ML 141 | Salirasib | Pan-RAS-IN-1 | Rhosin hydrochloride | CASIN | EHT 1864 | EHop-016 | 1A-116 | CCG 1423 | K-Ras(G12C) inhibitor 12 | ZCL 278 | Y16

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
676.3±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C22H23Cl2N3O3

[ Molecular Weight ]:
448.342

[ Flash Point ]:
362.8±31.5 °C

[ Exact Mass ]:
447.111633

[ LogP ]:
3.22

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
2-8℃

Related Compounds