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c-Fms-IN-9

Names

[ CAS No. ]:
1628574-50-4

[ Name ]:
c-Fms-IN-9

Biological Activity

[Description]:

c-Fms-IN-9 is a c-FMS inhibitor extracted from patent WO2014145023A1, Compound Example 7. c-Fms-IN-9 inhibits unphosphorylated c-FMS kinase (uFMS) and uKIT with IC50s of <0.01 μM and 0.1-1 μM, respectively[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

[Target]

c-FMS[1]


[In Vitro]

c-Fms-IN-9 inhibits M-NFS-60, THP-1 and osteoclast cells proliferation with IC50s of 0.01-0.1 μM[1].

[References]

[1]. Gary E. L. BRANDT, et al. 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities. WO2014145023A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C21H23N7O2

[ Molecular Weight ]:
405.45

Related Compounds