c-Fms-IN-6

Names

[ CAS No. ]:
1628574-81-1

[ Name ]:
c-Fms-IN-6

Biological Activity

[Description]:

c-Fms-IN-6 is a potent inhibitor of c-FMS, with an IC50 of ≤10 nM for unphosphorylated c-FMS, also weakly inhibits unphosphorylated c-KIT and PDGFR (IC50, > 1 μM). Used in the research of autoimmune diseases[1].

[Related Catalog]:

Research Areas >> Inflammation/Immunology
Signaling Pathways >> Protein Tyrosine Kinase/RTK >> c-Fms

[Target]

IC50: ≤10 nM (c-FMS)[1]


[In Vitro]

c-Fms-IN-6 (Example 38) shows inhibitory activity against M-NFS-60 cell proliferation, with an IC50 in the range of 0.01 μM to 0.1 μM[1].

[References]

[1]. Gary E. L. BRANDT, et al. 1,2,4-triazol-5-ones and analogs exhibiting anti-cancer and anti-proliferative activities. WO2014145023A1.

Chemical & Physical Properties

[ Molecular Formula ]:
C22H25N7O2

[ Molecular Weight ]:
419.48

Related Compounds