GR 103691

Names

[ CAS No. ]:
162408-66-4

[ Name ]:
GR 103691

[Synonym ]:
4'-Acetyl-N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}biphenyl-4-carboxamide
4'-Acetyl-N-{4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl}-4-biphenylcarboxamide
Tocris-1109
[1,1'-Biphenyl]-4-carboxamide, 4'-acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-
MFCD00936840

Biological Activity

[Description]:

GR 103691 is a potent, selective dopamine D3 receptor antagonist with a Ki value of 0.4 nM. GR 103691 shows more than 100-fold selectivity for human dopamine human (h)D3 over hD4 and hD1 sites[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor
Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Research Areas >> Neurological Disease

[Target]

Ki: 0.4 nM (Human dopamine D3 receptor)[1]


[In Vitro]

GR 103691 shows marked affinity for serotonin1A (5-HT1A) receptors (Ki of 5.8 nM) and α-1 adrenoceptors (Ki of 12.6 nM)[1].

[References]

[1]. Audinot V, et al. A comparative in vitro and in vivo pharmacological characterization of the novel dopamine D3 receptor antagonists (+)-S 14297, nafadotride, GR 103,691 and U 99194. J Pharmacol Exp Ther. 1998 Oct;287(1):187-97.

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
688.7±55.0 °C at 760 mmHg

[ Molecular Formula ]:
C30H35N3O3

[ Molecular Weight ]:
485.617

[ Flash Point ]:
370.3±31.5 °C

[ Exact Mass ]:
485.267853

[ PSA ]:
61.88000

[ LogP ]:
4.47

[ Vapour Pressure ]:
0.0±2.1 mmHg at 25°C

[ Index of Refraction ]:
1.582

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

Related Compounds