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BRCA1-IN-2

Names

[ CAS No. ]:
1622262-55-8

[ Name ]:
BRCA1-IN-2

Biological Activity

[Description]:

BRCA1-IN-2 (compound 15) is a cell-permeable protein-protein interaction (PPI) inhibitor for BRCA1 with an IC50 of 0.31 μM and a Kd of 0.3 μM, which shows antitumor activities via the disruption of BRCA1 (BRCT)2/protein interactions[1].

[Related Catalog]:

Research Areas >> Cancer
Signaling Pathways >> Epigenetics >> PARP
Signaling Pathways >> Cell Cycle/DNA Damage >> PARP

[Target]

IC50: 0.31 μM (BRCA1)[1] Kd: 0.3 μM (BRCA1)[1]


[References]

[1]. Na Z, et al. Protein-Protein Interaction Inhibitors of BRCA1 Discovered Using Small Molecule Microarrays. Methods Mol Biol. 2017;1518:139-156.

Chemical & Physical Properties

[ Molecular Formula ]:
C26H33N4O7P

[ Molecular Weight ]:
544.54

Related Compounds