DLK-IN-1

Names

[ CAS No. ]:
1620574-24-4

[ Name ]:
DLK-IN-1

Biological Activity

[Description]:

DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> MAPK/ERK Pathway >> MAP3K

[Target]

Ki: 3 nM (DLK)[1].

[References]

[1]. Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₀H₂₄F₃N₅O₂

[ Molecular Weight ]:
423.43

[ Storage condition ]:
2-8℃

Related Compounds

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