1620574-24-4

1620574-24-4 structure

Name: DLK-IN-1
Chemical Name: DLK-IN-1
CAS Number: 1620574-24-4
Molecular Formula: C₂₀H₂₄F₃N₅O₂
Molecular Weight: 423.43
Catalog: Signaling Pathways MAPK/ERK Pathway MAP3K
Create Date: 2019-03-03 10:57:11
Modify Date: 2024-02-04 22:37:31
DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.

Name	DLK-IN-1

Description	DLK-IN-1 is a selective inhibitor of dual leucine zipper kinase (DLK, MAP3K12), with a Ki of 3 nM. DLK-IN-1 retains excellent CNS penetration and is well tolerated following multiple days of dosing at concentrations that exceed those required for DLK inhibition in the brain. DLK-IN-1 has activity in a model of Alzheimer’s Disease.
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> MAPK/ERK Pathway >> MAP3K
Target	Ki: 3 nM (DLK)[1].
References	[1]. Patel S, et al. Selective Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12) with Activity in a Model of Alzheimer's Disease. J Med Chem. 2017 Oct 12;60(19):8083-8102.