Glicoricone

Names

[ Name ]:
Glicoricone

Biological Activity

[Description]:

Glicoricone, a phenolic compound, is isolated from a species of licorice. Glicoricone is an inhibitor of monoamine oxidase (MAO), with an IC50 of 140 μM. Glicoricone binds to estrogen receptor (ER) and shows estrogen antagonist activity[1][2].

[Related Catalog]:

Signaling Pathways >> Others >> Estrogen Receptor/ERR

Signaling Pathways >> Neuronal Signaling >> Monoamine Oxidase

Research Areas >> Metabolic Disease

[Target]

IC50: 140 μM (monoamine oxidase)[1]

[References]

[1]. Hatano T, et, al. Phenolic constituents of licorice. III. Structures of glicoricone and licofuranone, and inhibitory effects of licorice constituents on monoamine oxidase. Chem Pharm Bull (Tokyo). 1991 May;39(5):1238-43.

[2]. Boonmuen N, et, al. Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities. Steroids. 2016 Jan;105:42-9.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₁H₂₀O₆

[ Molecular Weight ]:
368.38

Related Compounds

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