1,4-Dithiothreitol
Names
[ CAS No. ]:
16096-97-2
[ Name ]:
1,4-Dithiothreitol
[Synonym ]:
Cleland reagent chiral
2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-
(2R,3R)-1,4-Disulfanyl-2,3-butanediol
1,4-Dithiothreitol
L-(−)-Dithiothreitol
1,4-Bissulfanylbutane-2,3-diol
DL-1,4-Dimercapto-2,3-dihydroxybutane
(2R,3R)-(-)-2,3-Dihydroxy-1,4-butanedithiol
1,4-Disulfanyl-2,3-butanediol
(R*,R*)-1,4-DIMERCAPTO-2,3-BUTANEDIOL
(2R,3R)-1,4-Disulfanylbutane-2,3-diol
2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-
L-Dithiothreitol
EINECS 240-263-0
(2R*,3S*)-1,4-dimercaptobutane-2,3-diol
dithiothreitol
threo-2,3-Dihydroxy-1,4-butanedithiol
(−)-Cleland's Reagent
(2R*,3S*)-1,4-dimercapto-2,3-butanediol
(2R,3R)-(-)-1,4-Dimercapto-2,3-butanediol
(2R,3R)-1,4-Dimercapto-2,3-butanediol
UNII:T8ID5YZU6Y
L-Cleland's
1,4-Disulfanylbutane-2,3-diol
2,3-Butanediol, 1,4-dimercapto-
(±)-1,4-Dimercapto-2,3-butanediol
(2R,3R)-1,4-dimercaptobutane-2,3-diol
MFCD00064305
Biological Activity
[Description]:
[Related Catalog]:
Chemical & Physical Properties
[ Density]:
1.3±0.1 g/cm3
[ Boiling Point ]:
364.5±42.0 °C at 760 mmHg
[ Melting Point ]:
42-44ºC
[ Molecular Formula ]:
C4H10O2S2
[ Molecular Weight ]:
154.251
[ Flash Point ]:
174.2±27.9 °C
[ Exact Mass ]:
154.012222
[ PSA ]:
118.06000
[ LogP ]:
0.07
[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C
[ Index of Refraction ]:
1.579
[ Storage condition ]:
−20°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EK1612000
- CHEMICAL NAME :
- 2,3-Butanediol, 1,4-dimercapto-, L-threo-
- CAS REGISTRY NUMBER :
- 16096-97-2
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C4-H10-O2-S2
- MOLECULAR WEIGHT :
- 154.26
- WISWESSER LINE NOTATION :
- SH1YQYQ1SH -L,THREO
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 179 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 15,600,1972
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H312-H315-H319-H335
[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn: Harmful;
[ Risk Phrases ]:
R21/22
[ Safety Phrases ]:
26-36/37
[ RIDADR ]:
UN 3335
[ WGK Germany ]:
3
[ RTECS ]:
EK1612000
[ Hazard Class ]:
9.0
[ HS Code ]:
2930909090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2930909090
[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Articles
Cancer Prev. Res. (Phila.) 8(3) , 208-21, (2015)
Exposure to toxicants leads to cumulative molecular changes that overtime increase a subject's risk of developing urothelial carcinoma. To assess the impact of arsenic exposure at a time progressive m...
The mTOR inhibitor rapamycin synergizes with a fatty acid synthase inhibitor to induce cytotoxicity in ER/HER2-positive breast cancer cells.PLoS ONE 9(5) , e97697, (2014)
Patients with ER/HER2-positive breast cancer have a poor prognosis and are less responsive to selective estrogen receptor modulators; this is presumably due to the crosstalk between ER and HER2. Fatty...
Matrix stiffening and β1 integrin drive subtype-specific fibroblast accumulation in lung cancer.Mol. Cancer Res. 13(1) , 161-73, (2015)
The crucial role of tumor-associated fibroblasts (TAF) in cancer progression is now clear in non-small cell lung cancer (NSCLC). However, therapies against TAFs are limited due to a lack of understand...