BW-723C86

Names

[ Name ]:
BW-723C86

[Synonym ]:
1-[5-(2-Thienylmethoxy)-1H-indol-3-yl]propan-2-amine hydrochloride (1:1)
1-[5-(thiophen-2-ylmethoxy)-1H-indol-3-yl]propan-2-amine,hydrochloride
1-[5-(2-Thienylmethoxy)-1H-indol-3-yl]-2-propanamine hydrochloride (1:1)
1H-Indole-3-ethanamine, α-methyl-5-(2-thienylmethoxy)-, hydrochloride (1:1)
MFCD01321066

Biological Activity

[Description]:

BW-723C86 is a potent and a selective 5-HT2B receptor agonist. BW-723C86 exhibits anxiolytic-like actions. BW-723C86 also causes hyperphagia and reduced grooming in rats[1][2][3].

[Related Catalog]:

Research Areas >> Neurological Disease

Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor

Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor

[Target]

5-HT2B Receptor

[References]

[1]. Kennett GA, et, al. BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats. Neuropharmacology. 1997 Feb;36(2):233-9.

[2]. Kennett GA, et, al. Anxiolytic-like actions of BW 723C86 in the rat Vogel conflict test are 5-HT2B receptor mediated. Neuropharmacology. 1998 Dec;37(12):1603-10.

[3]. Matsumoto T, et, al. Effect of Equol on Vasocontractions in Rat Carotid Arteries Treated with High Insulin. Biol Pharm Bull. 2019;42(6):1048-1053.

Chemical & Physical Properties

[ Boiling Point ]:
488.4ºC at 760 mmHg

[ Melting Point ]:
203 - 205 °C

[ Molecular Formula ]:
C₁₆H₁₉ClN₂OS

[ Molecular Weight ]:
322.853

[ Flash Point ]:
249.2ºC

[ Exact Mass ]:
322.090668

[ PSA ]:
79.28000

[ LogP ]:
5.20040

[ Vapour Pressure ]:
1.09E-09mmHg at 25°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NL8504715

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude.

J. Neurosci. 35 , 9580-94, (2015)

Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, des...

BW 723C86, a 5-HT2B receptor agonist, causes hyperphagia and reduced grooming in rats.

Neuropharmacology 36 , 233-239, (1997)

The 5-HT2B receptor agonist, BW 723C86 (10 and 20 mg/kg s.c.), increased the time spent in feeding behaviour of freely-fed rats in observation cages over 15 min. BW 723C86 (20 and 50 mg/kg s.c. 30 min...

Effects of the 5-HT2B receptor agonist, BW 723C86, on three rat models of anxiety.

Br. J. Pharmacol. 117 , 1443-1448, (1996)

1. BW 723C86 (3 and 10 mg kg-1, s.c. 30 min pretest), a 5-HT2B receptor agonist, increased total interaction, but not locomotion in a rat social interaction test, a profile consistent with anxiolysis....