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(Des-Arg9)-Bradykinin acetate salt

Names

[ CAS No. ]:
15958-92-6

[ Name ]:
(Des-Arg9)-Bradykinin acetate salt

[Synonym ]:
L-phenylalanine, N-[[(2S)-1-[(2S)-2-[[(1Z,2S)-2-[[(1E)-2-[[(1Z)-[(2S)-1-[[(2S)-1-[(2S)-2-amino-5-[(aminoiminomethyl)amino]-1-oxopentyl]-2-pyrrolidinyl]carbonyl]-2-pyrrolidinyl]hydroxymethylene]amino]-1-hydroxyethylidene]amino]-1-hydroxy-3-phenylpropylidene]amino]-3-hydroxy-1-oxopropyl]-2-pyrrolidinyl]hydroxymethylene]-, (Z)-
1-8-Bradykinin
des-arginine9-bradykinin
bradykinin fragment 1-8
9-Des-Arg-bk
[des-Arg(9)]-bradykinin
9-De-Arg-bradykinin
L-Phenylalanine, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-
des-Arg9-bradykinin
RPPGFSPF
DABK
N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-prolylglycyl-L-phenylalanyl-L-seryl-L-prolyl-L-phenylalanine
des-Arg9-BK
Bradykinin[Des-Arg9]

Biological Activity

[Description]:

[Des-Arg9]-Bradykinin is a Bradykinin (B1) receptor agonist that displays selectivity for B1 over B2 receptors.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor
Research Areas >> Inflammation/Immunology
Peptides

[Target]

Bradykinin (B1) receptor[1]


[In Vitro]

The B2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B1 receptor mediates the action of [Des-Arg9]-Bradykinin (des-Arg9-BK) and Lys-des-Arg Arg9-BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively[1].

[References]

[1]. Leeb-Lundberg LM, et al. International union of pharmacology. XLV. Classification of the kinin receptor family: from molecular mechanisms to pathophysiological consequences. Pharmacol Rev. 2005 Mar;57(1):27-77.


[Related Small Molecules]

HOE 140 TFA | Bradykinin | SSR240612 | ELN-441958 | [Des-Arg9]-Bradykinin acetate | Bradykinin (1-3) sulfate salt | Bradykinin Fragment 1-5 | Bradykinin (1-6) acetate salt | Bradykinin Fragment 1-7 | Bradykinin Fragment 2-9 | FR167344 free base

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Molecular Formula ]:
C44H61N11O10

[ Molecular Weight ]:
904.023

[ Exact Mass ]:
903.460266

[ PSA ]:
322.78000

[ LogP ]:
0.64

[ Index of Refraction ]:
1.687

[ Storage condition ]:
-20°C

Synthetic Route

Precursor & DownStream

Precursor

DownStream


Related Compounds

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