Bradykinin Fragment 2-9

Names

[ Name ]:
Bradykinin Fragment 2-9

[Synonym ]:
L-Phe-L-Trp-OH
H-PPGFSPFR-OH
bradykinin fragment 2-9
n-l-phenylalanyl-l-tryptopha
L-PHENYLALANYL-L-TRYPTOPHAN
Phe-Trp-OH
des-[Arg1]-bradykinin
phenylalanyltryptophane
des-Arg9-bradykinin
phenylalanyltryptophan
Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
Bradykinin (2-9)

Biological Activity

[Description]:

Bradykinin (2-9) is an amino-truncated Bradykinin peptide. Bradykinin (2-9) is a metabolite of Bradykinin, cleaved by Aminopeptidase P.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Bradykinin Receptor

Research Areas >> Cardiovascular Disease

Peptides

[In Vitro]

The Bradykinin peptide system is a tissue-based system with potent cardiovascular and renal effects. To investigate the regulation of this system, a highly sensitive amino terminal-directed radioimmunoassay that, with high performance liquid chromatography, enables the measurement of Bradykinin-(1-7), Bradykinin-(1-8), and Bradykinin-(1-9), is developed. Together with a carboxy terminal-directed radioimmunoassay, Bradykinin peptides in rat kidney and blood are characterized. The predominant Bradykinin peptides in kidney are Bradykinin-(1-9) (~100 fmol/g wet weight of tissue) and Bradykinin-(1-7) (~70 fmol/g), with low levels of Bradykinin-(1-8) (~8 fmol/g) and Bradykinin-(4-9) (~12 fmol/g) detectable; Bradykinin-(2-9) and Bradykinin-(3-9) are below the limits of detection. In blood, the levels of Bradykinin-(1-9) are very low (~2 fmol/ml), and other Bradykinin peptides are below the limits ofdetection. Administration of the angiotensin converting enzyme (ACE) inhibitor Perindopril is associated with an approximate twofold increase in renal levels of Bradykinin-(1-8) and Bradykinin-(1-9) and a decrease in the Bradykinin-(1-7)/Bradykinin-(1-9) ratio. The amino terminal-directed radioimmunoassay is also applied to heart, aorta, brown adipose tissue, adrenal, lung, and brain. For these tissues, Bradykinin-(1-7) and Bradykinin-(1-9) are of similar abundance (16-340 fmol/g), with lower levels of Bradykinin-(1-8)[1].

[References]

[1]. Campbell DJ, et al. Bradykinin peptides in kidney, blood, and other tissues of the rat. Hypertension. 1993 Feb;21(2):155-65.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.47g/cm3

[ Molecular Formula ]:
C₄₄H₆₁N₁₁O₁₀

[ Molecular Weight ]:
904.02300

[ Exact Mass ]:
903.46000

[ PSA ]:
317.58000

[ LogP ]:
0.95140

[ Index of Refraction ]:
1.684

[ Storage condition ]:
-20°C

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
F+

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3.0

Articles

Interaction between bradykinin and natriuretic peptides via RGS protein activation in HEK-293 cells.

Am. J. Physiol. Cell Physiol. 303(12) , C1260-8, (2012)

In this study, the interaction of natriuretic peptides (NP) and bradykinin (BK) signaling pathways was identified by measuring membrane potential (V(m)) and intracellular Ca(2+) using the patch-clamp ...

Accurate mass measurements using MALDI-TOF with delayed extraction.

J. Protein Chem. 16(5) , 363-9, (1997)

Matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry is now an essential tool in biopolymer analysis. Sensitivity and mass range are unsurpassed, but mass measureme...

Shattering of Peptide ions on self-assembled monolayer surfaces.

J. Am. Chem. Soc. 125(6) , 1625-32, (2003)

Time- and collision energy-resolved surface-induced dissociation (SID) of des-Arg(1)- and des-Arg(9)-bradykinin on a fluorinated self-assembled monolayer (SAM) surface was studied by use of a novel Fo...

Related Compounds

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