2-Hydrazinyl-adenosine

Names

[ Name ]:
2-Hydrazinyl-adenosine

[Synonym ]:
(2R,3R,4S,5R)-2-(6-amino-2-hydrazinylpurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol

Biological Activity

[Description]:

2-Hydrazinyl-adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog

[References]

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

Chemical & Physical Properties

[ Density]:
2.29±0.1 g/cm3(Predicted)

[ Boiling Point ]:
583.1±60.0 °C(Predicted)

[ Melting Point ]:
208-210ºC

[ Molecular Formula ]:
C₁₀H₁₅N₇O₄

[ Molecular Weight ]:
297.27

[ Exact Mass ]:
297.11900

[ PSA ]:
177.59000

[ Index of Refraction ]:
2.002

[ Storage condition ]:
2-8°C

Safety Information

[ Hazard Codes ]:
Xn

2-Hydrazinyl-adenosine

Names

Biological Activity

Chemical & Physical Properties

Safety Information

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream