Cecropin A (1-7)-Melittin A (2-9) amide trifluoroacetate salt

Names

[ Name ]:
Cecropin A (1-7)-Melittin A (2-9) amide trifluoroacetate salt

[Synonym ]:
H-LYS-TRP-LYS-LEU-PHE-LYS-LYS-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-NH2
CECROPIN A-MELITTIN HYBRID PEPTIDE
LYS-TRP-LYS-LEU-PHE-LYS-LYS-ILE-GLY-ALA-VAL-LEU-LYS-VAL-LEU-NH2
KWKLFKKIGAVLKVL-NH2
KWKLFKKIGAVLKVL-amide

Biological Activity

[Description]:

Cecropin A (1-7)-Melittin A (2-9) is an antimicrobial peptide with antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative aerobic bacteria, as well as antimalarial activity, without the adverse hemolytic properties of bee venom peptides[1].

[Related Catalog]:

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Bacterial

[In Vitro]

Cecropin A (1-7)-Melittin A (2-9) (0-64 mg/L, 48 h) 作用于E. coli ATCC 25922, Staphylococcus aureus ATCC 29213, B. fragilis NCTC 9343 和 C. pefringens ATCC 13124 的 MIC 值分别为 8 mg/L, 32 mg/L, 8 mg/L and 64 mg/L[1]。

[References]

[1]. Charlotta Edlund, et al. Antianaerobic activity of a cecropin---melittin peptide. Clin Microbiol Infect. 1998 Apr;4(4):181-185.

Chemical & Physical Properties

[ Molecular Formula ]:
C₈₉H₁₅₂N₂₂O₁₅

[ Molecular Weight ]:
1770.30000

[ Exact Mass ]:
1769.18000

[ PSA ]:
622.40000

[ LogP ]:
10.72030

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Related Compounds

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