Ertapenem Sodium

Names

[ Name ]:
Ertapenem Sodium

[Synonym ]:
2',4',6',3,4-PENTAHYDROXYDIHYDROCHALCONE
eriodictoyl dihydrochalcone
2',4',6',3,4-PENTAHYDROXYLDIHYDROCHALCONE
3-hydoxyphloretin
sodium,3-[[(2S,4S)-4-[[(4R,5S,6S)-2-carboxy-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl]sulfanyl]pyrrolidine-2-carbonyl]amino]benzoate
3'-hydroxyphloretin

Biological Activity

[Description]:

Ertapenem sodium is a new long-acting 1-β-methyl carbapenem antibiotic with a broad antibacterial spectrum including common aerobic and anaerobic bacteria and organisms with extended-spectrum β-lactamases.

[Related Catalog]:

Signaling Pathways >> Anti-infection >> Bacterial

Research Areas >> Infection

[References]

[1]. Hoellman DB, et al. In vitro antianaerobic activity of ertapenem (MK-0826) compared to seven other compounds. Antimicrob Agents Chemother. 2002 Jan;46(1):220-4.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
813.9ºC at 760 mmHg

[ Molecular Formula ]:
C₂₂H₂₄N₃NaO₇S

[ Molecular Weight ]:
497.49700

[ Flash Point ]:
446ºC

[ Exact Mass ]:
497.12300

[ PSA ]:
184.40000

[ Vapour Pressure ]:
5.26E-28mmHg at 25°C

[ Storage condition ]:
-20℃

[ Water Solubility ]:
Fully miscible in water. Soluble in DMSO.

Safety Information

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Articles

Neutrophil Extracellular Traps Induce Organ Damage during Experimental and Clinical Sepsis.

PLoS ONE 11 , e0148142, (2016)

Organ dysfunction is a major concern in sepsis pathophysiology and contributes to its high mortality rate. Neutrophil extracellular traps (NETs) have been implicated in endothelial damage and take par...

The Effect of Radiation Dose and Variation in Neupogen® Initiation Schedule on the Mitigation of Myelosuppression during the Concomitant GI-ARS and H-ARS in a Nonhuman Primate Model of High-dose Exposure with Marrow Sparing.

Health Phys. 109 , 427-39, (2015)

A nonhuman primate (NHP) model of acute high-dose, partial-body irradiation with 5% bone marrow (PBI/BM5) sparing was used to assess the effect of Neupogen® [granulocyte colony stimulating factor (G-C...