PD 145065

Names

[ Name ]:
PD 145065

Biological Activity

[Description]:

PD 145065 is a highly potent but non-selective endothelin receptor antagonist with an IC50 value of 4 nM for the ETA receptor for rabbit renal artery vascular smooth muscle cells[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Warner TD, et al. Reversal of established responses to endothelin-1 in vivo and in vitro by the endothelin receptor antagonists, BQ-123 and PD 145065. Br J Pharmacol. 1994 May;112(1):207-13.

Chemical & Physical Properties

[ Density]:
1.24g/cm3

[ Boiling Point ]:
1252.1ºC at 760mmHg

[ Molecular Formula ]:
C₅₂H₆₇N₇O₁₀

[ Molecular Weight ]:
950.12900

[ Exact Mass ]:
949.49500

[ PSA ]:
264.99000

[ LogP ]:
6.61280

[ Vapour Pressure ]:
0mmHg at 25°C

[ Index of Refraction ]:
1.59

Related Compounds

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