PD 168568 dihydrochloride

Names

[ CAS No. ]:
1782532-06-2

[ Name ]:
PD 168568 dihydrochloride

Biological Activity

[Description]:

PD 168568 dihydrochloride is an orally active and selective D4 dopamine receptor antagonist, with a Ki of 8.8 nM[1].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor

Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor

Research Areas >> Neurological Disease

[Target]

D4 Receptor:8.8 nM (Ki)

[In Vitro]

PD 168568 dihydrochloride has good selective for D4 receptor, with a Ki of 1842 nM for D2 receptor[1].

[In Vivo]

PD 168568 dihydrochloride has ability to inhibit amphetamine stimulated locomotor activity in the rat[1]. Animal Model: Rat[1] Dosage: 3 mg/kg Administration: Oral administration Result: Inhibit amphetamine (0.5 mg/kg, i.p.) stimulated locomotor activity.

[References]

[1]. Belliotti TR, et al. Isoindolinone enantiomers having affinity for the dopamine D4 receptor. Bioorg Med Chem Lett. 1998 Jun 16;8(12):1499-502.

Chemical & Physical Properties

[ Molecular Formula ]:
C₂₂H₂₉Cl₂N₃O

[ Molecular Weight ]:
422.39

[ Storage condition ]:
2-8°C

PD 168568 dihydrochloride

Names

Biological Activity

Chemical & Physical Properties

Related Compounds