AB-MECA

Names

[ CAS No. ]:
152918-26-8

[ Name ]:
AB-MECA

[Synonym ]:
N6-(4-Aminobenzyl)-N-methylcarboxamidoadenosine
[3H]AB-MECA
AB-MECA

Biological Activity

[Description]:

AB-MECA is a high affinity A3 adenosine receptor agonist, has high affinity for recombinant A1 and A3 receptors.

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adenosine Receptor

Research Areas >> Neurological Disease

[References]

[1]. Shearman LP, et al. [125I]4-aminobenzyl-5'-N-methylcarboxamidoadenosine (125I)AB-MECA) labels multiple adenosine receptorsubtypes in rat brain. Brain Res. 1997 Jan 16;745(1-2):10-20.

[Related Small Molecules]

Chemical & Physical Properties

[ Density]:
1.68g/cm3

[ Molecular Formula ]:
C₁₈H₂₁N₇O₄

[ Molecular Weight ]:
399.40400

[ Exact Mass ]:
399.16600

[ PSA ]:
163.93000

[ LogP ]:
0.88030

[ Index of Refraction ]:
1.789

[ Storage condition ]:
2-8℃

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

Articles

125I-4-aminobenzyl-5'-N-methylcarboxamidoadenosine, a high affinity radioligand for the rat A3 adenosine receptor.

Mol. Pharmacol. 45 , 978-982, (1994)

The rat A3 adenosine receptor (AR) is a recently characterized AR subtype cloned from testis and brain cDNA libraries. N6-2-(4-Amino-3-[125I]iodophenyl)ethyladenosine, a high affinity A1AR agonist, ha...

A role for central A3-adenosine receptors. Mediation of behavioral depressant effects.

FEBS Lett. 336 , 57-60, (1993)

The behavioral effects of a selective A3 adenosine receptor agonist 3-IB-MECA (N6-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine) in mice and the localization of radioligand binding sites in mouse bra...

Structure-activity relationships of N6-benzyladenosine-5'-uronamides as A3-selective adenosine agonists.

J. Med. Chem. 37 , 636-646, (1994)

Adenosine analogues modified at the 5'-position as uronamides and/or as N6-benzyl derivatives were synthesized. These derivatives were examined for affinity in radioligand binding assays at the newly ...

Related Compounds

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.