L-Histidine, N-formyl-

Names

[ Name ]:
L-Histidine, N-formyl-

[Synonym ]:
(S)-2-Formamido-3-(1H-imidazol-4-yl)propanoic acid
N-Formyl-L-histidine
N-formyl histidine
Einecs 239-248-1
Formylhistidine
FOR-HIS-OH

Biological Activity

[Description]:

N-Formyl-L-histidine shows binding affinity to histidyl-tRNA synthetase with a Ki value of 4.6 μM. N-Formyl-L-histidine shows a competitive inhibition against L-histidine ammonia-lyase, inhibits urocanic acid formation from L-histidine with a Ki value of 4.26 mM[1][2].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Lepore GC, et al. Histidyl-tRNA synthetase from Salmonella typhimurium: specificity in the binding of histidine analogues. Eur J Biochem. 1975 Aug 15;56(2):369-74.

[2]. Shibatani T, et al. Crystalline L-histidine ammonia-lyase of Achromobacter liquidum. Crystallization and enzymic properties. Eur J Biochem. 1975 Jun 16;55(1):263-9.

Chemical & Physical Properties

[ Density]:
1.51g/cm3

[ Boiling Point ]:
442.9ºC at 760mmHg

[ Melting Point ]:
202.0 to 206.0 °C

[ Molecular Formula ]:
C₇H₉N₃O₃

[ Molecular Weight ]:
183.16500

[ Flash Point ]:
221.6ºC

[ Exact Mass ]:
183.06400

[ PSA ]:
95.08000

[ LogP ]:
0.17820

[ Vapour Pressure ]:
1.72E-17mmHg at 25°C

[ Index of Refraction ]:
58 ° (C=2, H2O)

[ Water Solubility ]:
almost transparency

MSDS

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Safety Information

[ Safety Phrases ]:
S22-S24/25

[ HS Code ]:
2933290090

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933290090

[ Summary ]:
2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%