alphaSYN-IN-NAB2

Names

[ Name ]:
alphaSYN-IN-NAB2

[Synonym ]:
N-(2-chlorobenzyl)-1-(2,5-dimethylphenyl)benzimidazole-5-carboxamide
N-(2-Chlorobenzyl)-1-(2,5-dimethylphenyl)-1H-benzimidazole-5-carboxamide
NAB 2
MFCD28976190
1H-Benzimidazole-5-carboxamide, N-[(2-chlorophenyl)methyl]-1-(2,5-dimethylphenyl)-

Biological Activity

[Description]:

NAB2 is a neuron-protective agent. NAB2 strongly and selectively protects diverse cell types from α-syn toxicity. NAB2 promots endosomal transport events dependent on the E3 ubiquitin ligase Rsp5/Nedd4. NAB2 identifies a druggable node in the biology of α-syn that can correct multiple aspects of its underlying pathology, including dysfunctional endosomal and endoplasmic reticulum-to-Golgi vesicle trafficking[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others

Research Areas >> Neurological Disease

[References]

[1]. Tardiff DF, et al. Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons. Science. 2013;342(6161):979-983.

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Molecular Formula ]:
C₂₃H₂₀ClN₃O

[ Molecular Weight ]:
389.877

[ Exact Mass ]:
389.129486

[ LogP ]:
5.88

[ Index of Refraction ]:
1.643

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319-H413

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P337 + P313

[ RIDADR ]:
NONH for all modes of transport

Related Compounds

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