GR-127935 hydrochloride
Names
[ CAS No. ]:
148642-42-6
[ Name ]:
GR-127935 hydrochloride
[Synonym ]:
N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-4-[2-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl]benzamide,hydrochloride
Biological Activity
[Description]:
GR127935 hydrochloride is a potent and orally active 5-HT1D and 5-HT1B receptor antagonist with pKis of 8.5 for both isoforms. GR127935 hydrochloride has 100-fold selectivity for 5-HT1B/1D receptors over 5-HT1A, 5-HT2A, and 5-HT2C receptors. GR127935 hydrochloride can be used in neurological disease research[1][2].
[Related Catalog]:
[Target]
5-HT1B Receptor:8.5 (pKi)
5-HT1D Receptor:8.5 (pIC50)
[References]
Chemical & Physical Properties
[ Molecular Formula ]:
C29H32ClN5O3
[ Molecular Weight ]:
534.04900
[ Exact Mass ]:
533.21900
[ PSA ]:
83.73000
[ LogP ]:
5.91100