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Nef-IN-B9

Names

[ CAS No. ]:
1473404-51-1

[ Name ]:
Nef-IN-B9

Biological Activity

[Description]:

Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM; also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79 nM.

[References]

References 1. Emert-Sedlak LA, et al. Chem Biol. 2013 Jan 24;20(1):82-91. View Related Products by Target HIV

Chemical & Physical Properties

[ Molecular Formula ]:
C16H11ClN6O3S

[ Molecular Weight ]:
402.813


Related Compounds

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