1473404-51-1
1473404-51-1 structure
- Name: Nef-IN-B9
- Chemical Name: Nef-IN-B9
- CAS Number: 1473404-51-1
- Molecular Formula: C16H11ClN6O3S
- Molecular Weight: 402.813
- Catalog: Signaling Pathways Anti-infection HIV
- Create Date: 2020-01-12 09:44:50
- Modify Date: 2024-01-15 13:30:46
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Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM; also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79 nM.
| Name | Nef-IN-B9 |
|---|
| Description | Nef-IN-B9 (Nef inhibitor B9) is a small molecule that blocks Nef-dependent Hck activity with IC50 of 2.8 uM, while the activity against Hck alone is >20 uM; also showes weak activity against other Src-family members with IC50 of >20 uM for c-Src, Lck and Lyn; blocks wild-type HIV-1 replication with IC50 of 100-300 nM, and blocks Nef-mediated SFK activation in HIV-infected cells; binds directly to Nef with Kd of 1.79 nM. |
|---|---|
| References | References 1. Emert-Sedlak LA, et al. Chem Biol. 2013 Jan 24;20(1):82-91. View Related Products by Target HIV |
| Molecular Formula | C16H11ClN6O3S |
|---|---|
| Molecular Weight | 402.813 |