Dexmedetomidine hydrochloride

Names

[ Name ]:
Dexmedetomidine hydrochloride

[Synonym ]:
4-[(a-Methyl)-2,3-dimethylbenzyl]imidazole Monohydrochloride
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)
Dexdor
1H-imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, monohydrochloride
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole,hydrochloride
MFCD07772269
1H-Imidazole, 4-[(1S)-1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
UNII:BH210P244U
UNII-1018WH7F9I
4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole Monohydrochloride
5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole hydrochloride
Precedex
(S)-4-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole Monohydrochloride
1H-Imidazole, 4-[1-(2,3-dimethylphenyl)ethyl]-, hydrochloride (1:1)
Dexmedetomidine HCL
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride (1:1)
4-((S)-a,2,3-Trimethylbenzyl)imidazole Monohydrochloride
(±)-4-(a,2,3-Trimethylbenzyl)imidazole Monohydrochloride
Dexmedetomidine Hydrochloride
4-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolhydrochlorid
4-[(1S)-1-(2,3-diméthylphényl)éthyl]-1H-imidazole chlorhydrate
Dexmedetomidine HCl
4-(S)-[1-(2,3-DIMETHYLPHENYL)ETHYL]-1 H-IMIDAZOLE MONOHY DROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE)
Dexmedetomidine (hydrochloride)

Biological Activity

[Description]:

Dexmedetomidine Hydrochloride is an agonist of adrenergic alpha-2 receptor, which is used in veterinary medicine for its analgesic and sedative properties.Target: Adrenergic alpha-2 ReceptorDexmedetomidine, acting at alpha(2A) adrenoceptors, must be present during the encoding process to decrease discrete cue fear memory; however, its ability to suppress contextual memory is likely the result of blocking the consolidation process [1]. Dexmedetomidine had no analgesic effects in alpha(2A)-adrenoceptor KO mice [2]. Dexmedetomidine was effective in blocking these sympathomimetic actions of cocaine even in all 7 subjects who were homozygous for the Del322-325 polymorphism in the alpha2C AR, a loss-of-function mutation that is highly enriched in blacks [3].

[Related Catalog]:

Signaling Pathways >> GPCR/G Protein >> Adrenergic Receptor

Signaling Pathways >> Autophagy >> Autophagy

Research Areas >> Neurological Disease

[References]

[1]. Davies, M.F., et al., Activation of alpha2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 2004. 29(2): p. 229-39.

[2]. Ozdogan, U.K., et al., The involvement of alpha 2A-adrenoceptors in morphine analgesia, tolerance and withdrawal in mice. Eur J Pharmacol, 2004. 497(2): p. 161-71.

[3]. Menon, D.V., et al., Central sympatholysis as a novel countermeasure for cocaine-induced sympathetic activation and vasoconstriction in humans. J Am Coll Cardiol, 2007. 50(7): p. 626-33.

[Related Small Molecules]

Chemical & Physical Properties

[ Boiling Point ]:
381.9ºC at 760 mmHg

[ Melting Point ]:
153 - 158ºC

[ Molecular Formula ]:
C₁₃H₁₇ClN₂

[ Molecular Weight ]:
236.740

[ Exact Mass ]:
236.108032

[ PSA ]:
28.68000

[ LogP ]:
3.98030

[ Vapour Pressure ]:
1.08E-05mmHg at 25°C

[ Storage condition ]:
Desiccate at RT

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36/37/38

[ Safety Phrases ]:
26-36/37/39

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NI5156750

Articles

Effect of corneal contact lens wear on healing time and comfort post LGK for treatment of SCCEDs in boxers.

Vet. Ophthalmol. 18 , 364-70, (2015)

To determine whether dogs with spontaneous chronic corneal epithelial defects (SCCEDs) would heal faster and with an improved comfort score following linear grid keratotomy (LGK) combined with corneal...

Repeated exposure to MDMA triggers long-term plasticity of noradrenergic and serotonergic neurons.

Mol. Psychiatry 19(7) , 823-33, (2014)

3,4-Methylenedioxymethamphetamine (MDMA or 'ecstasy') is a psychostimulant drug, widely used recreationally among young people in Europe and North America. Although its neurotoxicity has been extensiv...

Optimized on-line enantioselective capillary electrophoretic method for kinetic and inhibition studies of drug metabolism mediated by cytochrome P450 enzymes.

Electrophoresis 36 , 1349-57, (2015)

Pharmacokinetic and pharmacodynamic properties of a chiral drug can significantly differ between application of the racemate and single enantiomers. During drug development, the characteristics of can...