2-Chloropyrazine

Names

[ Name ]:
2-Chloropyrazine

[Synonym ]:
2-Chloro-pyrazine
2-chloropyrazin
2-Dichloropyrazine
Pyrazine,chloro
Pyrazine, 2-chloro-
2-chloro-1,4-pyrazine
2-Chloro-1,4-diazine
chloro-pyrazin
EINECS 238-517-0
MFCD00006124
Chloropyrazine
pyrazine chloride
2-Cl-pyrazine
CHLOROPYRAZINE,2

Biological Activity

[Description]:

Chloropyrazine (Pyrazin-2-yl chloride) is a member of pyrazines, can be used for the synthesis of active compounds[1].

[Related Catalog]:

Research Areas >> Others

Signaling Pathways >> Others >> Others

[References]

[1]. Mosrin M, et al. Regio- and chemoselective multiple functionalization of chloropyrazine derivatives. Application to the synthesis of coelenterazine. Org Lett. 2009 Aug 6;11(15):3406-9.

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
155.3±20.0 °C at 760 mmHg

[ Molecular Formula ]:
C₄H₃ClN₂

[ Molecular Weight ]:
114.533

[ Flash Point ]:
57.8±0.0 °C

[ Exact Mass ]:
113.998474

[ PSA ]:
25.78000

[ LogP ]:
0.64

[ Vapour Pressure ]:
3.9±0.3 mmHg at 25°C

[ Index of Refraction ]:
1.535

[ Water Solubility ]:
INSOLUBLE

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H226-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
UN 1993 3/PG 3

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
3

[ HS Code ]:
29339990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Cobalt-catalyzed cross-coupling between in situ prepared arylzinc halides and 2-chloropyrimidine or 2-chloropyrazine.

J. Org. Chem. 74(8) , 3221-4, (2009)

A cobalt-catalyzed cross-coupling of aryl halides with 2-chloropyrimidines or 2-chloropyrazines is reported in satisfactory to high yields. The key step of this procedure is the formation of aromatic ...

Gas chromatographic assay for the new antitumor agent pyrazine-2-diazohydroxide (diazohydroxide) and its stability in buffer, blood and plasma.

J. Chromatogr. A. 383(1) , 77-83, (1986)

Diazohydroxide is a new antitumor agent being considered for clinical trial. A sensitive and specific assay for diazohydroxide in physiological media, plasma and blood has been developed based on conv...