Isograndifoliol

Names

[ Name ]:
Isograndifoliol

Biological Activity

[Description]:

Isograndifoliol is a selective inhibitor of butyrylcholinesterase (BChE) with an IC50 value of 0.9 μM. And Isograndifoliol moderately inhibits acetylcholinesterase (AChE) with an IC50 value of 342.9 μM. Isograndifoliol also has vasorelaxant effect and anti-tumor effect. Isograndifoliol can be used for research against dementia caused by neurodegenerative diseases[1][2][3].

[Related Catalog]:

Research Areas >> Cancer

Research Areas >> Cardiovascular Disease

Research Areas >> Neurological Disease

Signaling Pathways >> Neuronal Signaling >> AChE

[Target]

AChE:342.9 μM (IC50)

BChE:0.9 μM (IC50)

[In Vitro]

Isograndifoliol 对氯化钾或去甲肾上腺素预缩大鼠主动脉环具有剂量依赖性的血管松弛作用，EC50值为 36.36-74.51 μg/mL[2]。 Isograndifoliol 对 HL-60 细胞有较强的抑制活性，IC50 值为 0.33 μM[3]。

[References]

[1]. Ślusarczyk S, et al. Norditerpenoids with Selective Anti-Cholinesterase Activity from the Roots of Perovskia atriplicifolia Benth. Int J Mol Sci. 2020 Jun 23;21(12):4475.

[2]. Kang J, et al. Isolation and bioactivity of diterpenoids from the roots of Salvia grandifolia. Phytochemistry. 2015 Aug;116:337-348.

[3]. Tsukada H, et al. Two New Diterpenoids from Salvia przewarskii. Nat Prod Commun. 2016 Feb;11(2):159-61.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₉H₂₆O₃

[ Molecular Weight ]:
302.41

Related Compounds

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